Much of our knowledge about tumors dates from antiquity. Similarly, carcinogenesis or chemotherapy is incomprehensible without knowledge of what a malignant cell is and how it behaves. Metastasis is difficult to understand without a prior foundation in the concepts of pathology.
But we start with an examination of what cancer is to help you get a better grasp of the material that follows. Most textbooks of cancer biology begin with a discussion of cells. Both are important to understanding the origin of cancer cells, and such comprehension may lead to new modalities for treating cancers. This progression of events is also examined.Īn appreciation of embryology leads to a consideration of the origin of stem cells and the concepts of determination and differentiation. Tumors, with time, undergo changes that lead to autonomy.
This chapter defines terminology, compares and contrasts malignant and benign tumors, considers characteristics and behavior of malignant cells, and discusses how invading malignancies kill an individual. Our first task is to provide you with a working knowledge of the pathologic terms and concepts used throughout the text.
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